Castrucci G, Frigeri F, Cilli V, Tesei B, Arush A M, Pedini B, Ranucci S, Rampichini L
Am J Vet Res. 1980 Nov;41(11):1890-3.
A study was carried out to determine whether bovid herpesvirus-2 (BHV-2) is able to induce a recurrent infection in experimentally infected calves. Twelve calves infected with the virus were treated with dexamethasone (DMS) beginning 69 days after the infection, ie, several weeks after the animals had recovered from the disease and were negative for BHV-2. The stress induced by DMS treatment failed to reactivate the clinical condition or to induce shedding of BHV-2. However, treatment with DMS reactivated a latent infectious bovine rhinotracheitis (IBR) virus infection in all calves previously inoculated with BHV-2, and also in 2 noninoculated controls. The reactivation of IBR virus occurred without any clinical evidence of the disease, but the virus was isolated from nasal and pharyngeal swabbings and from the organs. A proliferative ganglionitis of the trigeminal ganglion was also observed. Because of the interference by IBR virus, this study did not resolve the question as to whether BHV-2 can induce a recurrent infection.
开展了一项研究，以确定牛疱疹病毒2型（BHV - 2）是否能够在实验感染的犊牛中引发复发性感染。12头感染该病毒的犊牛在感染后69天开始接受地塞米松（DMS）治疗，即在动物从疾病中康复且BHV - 2检测呈阴性数周后。DMS治疗所诱导的应激未能使临床症状重新出现，也未诱导BHV - 2的排出。然而，DMS治疗使所有先前接种过BHV - 2的犊牛以及2头未接种的对照犊牛中潜伏的传染性牛鼻气管炎（IBR）病毒感染重新激活。IBR病毒的重新激活未伴有该疾病的任何临床证据，但从鼻拭子、咽拭子以及器官中分离出了该病毒。还观察到三叉神经节的增生性神经炎。由于IBR病毒的干扰，这项研究未能解决BHV - 2是否能够诱导复发性感染的问题。
