Sigworth F J
Biophys J. 1981 Apr;34(1):111-33. doi: 10.1016/S0006-3495(81)84840-0.
A theory is presented which relates the nonstationary autocovariance (covariance) function to the kinetics of independently-gated ionic channels. The experimental covariance was calculated from ensembles of 256--504 current records elicited from single, voltage-clamped, frog myelinated nerve fibers. Analysis of the covariance shows that the decay of channels from conducting to nonconducting states proceeds more slowly late in a depolarization to near 0 mV, as compared with early in the same depolarization. This behavior is inconsistent with there being only one kinetic state corresponding to the open channel. The behavior can be explained by the existence of multiple kinetic states corresponding to the open channel, or, alternatively, by the existence of multiple, kinetically distinct populations of channels.
提出了一种将非平稳自协方差（协方差）函数与独立门控离子通道动力学相关联的理论。实验协方差是根据从单个电压钳制的青蛙有髓神经纤维引出的256 - 504个电流记录的集合计算得出的。协方差分析表明，与同一去极化早期相比，通道从导通状态转变为非导通状态的衰减在去极化后期接近0 mV时进行得更慢。这种行为与仅存在一种对应于开放通道的动力学状态不一致。这种行为可以通过存在对应于开放通道的多个动力学状态来解释，或者通过存在多个动力学上不同的通道群体来解释。
