脾切除术对仓鼠阿米巴肝脓肿大小及转移灶的影响。
Effect of splenectomy on the size of amoebic liver abscesses and metastatic foci in hamsters.
作者信息
Ghadirian E, Meerovitch E
出版信息
Infect Immun. 1981 Feb;31(2):571-3. doi: 10.1128/iai.31.2.571-573.1981.
Abstract
The role of the spleen in hepatic amoebiasis in hamsters was studied. In hamsters receiving an intrahepatic inoculation of 10(5) trophozoites of axenic Entamoeba histolytica at 7 or 14 days postsplenectomy, the mean weight of metastatic foci increased significantly when compared with sham-splenectomized or intact controls. In contrast, when both splenectomy and intrahepatic inoculation with amoebae were carried out at the same time, there was not only a significant increase in the mean weight of metastatic foci but also in the liver abscess. It is suggested that the spleen is important for host defense against E. histolytica infection, especially in the reduction in the degree of metastatic spread from the primary site.
摘要
研究了脾脏在仓鼠肝阿米巴病中的作用。在脾切除术后7天或14天接受肝内接种10(5) 无菌溶组织内阿米巴滋养体的仓鼠中，与假脾切除或完整对照相比，转移灶的平均重量显著增加。相反，当同时进行脾切除和肝内接种阿米巴时，不仅转移灶的平均重量显著增加，肝脓肿也显著增加。提示脾脏对宿主防御溶组织内阿米巴感染很重要，尤其是在减少原发部位转移扩散程度方面。
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