Ghadirian E, Meerovitch E
Parasite Immunol. 1982 Jul;4(4):219-25. doi: 10.1111/j.1365-3024.1982.tb00433.x.
The role of macrophages in hepatic amoebiasis in hamsters has been investigated by means of their treatment with bacille Calmette-Guérin (BCG) for activation, and with silica for elimination of these cells. Silica-treated animals inoculated intrahepatically with 1 x 10(5) trophozoites of Entamoeba histolytica developed amoebic abscesses in the liver and more metastases to other organs than control animals, and this effect was silica-dose-dependent. In contrast, BCG-treated animals developed significantly smaller abscesses in the liver and fewer metastatic foci. These data suggest that macrophages are involved in host defence against the establishment of amoebic liver abscess and metastatic dissemination of amoebae.
通过用卡介苗（BCG）处理以激活巨噬细胞以及用二氧化硅消除这些细胞，研究了巨噬细胞在仓鼠肝阿米巴病中的作用。经二氧化硅处理的动物经肝内接种1×10⁵个溶组织内阿米巴滋养体后，肝脏出现阿米巴脓肿，且转移至其他器官的情况比对照动物更多，这种效应呈二氧化硅剂量依赖性。相比之下，经卡介苗处理的动物肝脏脓肿明显较小，转移灶也较少。这些数据表明，巨噬细胞参与宿主对抗阿米巴肝脓肿形成和阿米巴转移播散的防御。
