巨噬细胞在仓鼠宿主抵御肝阿米巴病中的作用。
Role of macrophages in host defense against hepatic amoebiasis in hamsters.
作者信息
Ghadirian E, Meerovitch E, Kongshavn P A
出版信息
Infect Immun. 1983 Dec;42(3):1017-9. doi: 10.1128/iai.42.3.1017-1019.1983.
The role of macrophages in hepatic amoebiasis in hamsters has been investigated by means of antimacrophage serum prepared in rabbits. Animals treated with normal rabbit serum or antimacrophage serum, as well as untreated controls, were inoculated intrahepatically with 10(5) axenic trophozoites of Entamoeba histolytica. In hamsters treated with antimacrophage serum before intrahepatic inoculation of amoebae, the mean weight of the metastatic foci was significantly greater than in normal rabbit serum-treated or untreated controls. Treatment of hamsters with antimacrophage serum both before and after administration of amoebae not only increased significantly the size of the abscess in the liver but also allowed dissemination of metastatic foci to other organs.
通过在兔体内制备的抗巨噬细胞血清，研究了巨噬细胞在仓鼠肝阿米巴病中的作用。用正常兔血清或抗巨噬细胞血清处理的动物以及未处理的对照动物，均经肝内接种10⁵ 无共生体的溶组织内阿米巴滋养体。在肝内接种阿米巴之前用抗巨噬细胞血清处理的仓鼠，转移灶的平均重量显著大于用正常兔血清处理的或未处理的对照仓鼠。在给予阿米巴之前和之后均用抗巨噬细胞血清处理仓鼠，不仅显著增大了肝脏脓肿的大小，还使转移灶扩散到其他器官。
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