免疫细胞的体外杀阿米巴活性。
In vitro amoebicidal activity of immune cells.
作者信息
Ghadirian E, Meerovitch E
出版信息
Infect Immun. 1982 Apr;36(1):243-6. doi: 10.1128/iai.36.1.243-246.1982.
Abstract
The amoebicidal activity of peripheral blood lymphocytes and spleen and peritoneal cells from hamsters vaccinated against or protected from hepatic amoebiasis and from those with hepatic amoebiasis was investigated. Peripheral blood lymphocytes and peritoneal and spleen cells from vaccinated or protected animals can kill trophozoites of Entamoeba histolytica in vitro. In contrast, spleen cells from infected hamsters showed no significant cytotoxic effect on the parasite. These data suggest that cellular immunity plays an important role in host defense against hepatic amoebiasis.
摘要
对接种过疫苗或已免受肝阿米巴病侵害的仓鼠以及患有肝阿米巴病的仓鼠的外周血淋巴细胞、脾脏细胞和腹膜细胞的杀阿米巴活性进行了研究。来自接种过疫苗或已受保护动物的外周血淋巴细胞、腹膜细胞和脾脏细胞在体外可杀死溶组织内阿米巴滋养体。相比之下，感染仓鼠的脾脏细胞对该寄生虫未显示出明显的细胞毒性作用。这些数据表明，细胞免疫在宿主抵御肝阿米巴病中发挥着重要作用。
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