免疫细胞的体外杀阿米巴活性。
In vitro amoebicidal activity of immune cells.
作者信息
Ghadirian E, Meerovitch E
出版信息
Infect Immun. 1982 Apr;36(1):243-6. doi: 10.1128/iai.36.1.243-246.1982.
Abstract
The amoebicidal activity of peripheral blood lymphocytes and spleen and peritoneal cells from hamsters vaccinated against or protected from hepatic amoebiasis and from those with hepatic amoebiasis was investigated. Peripheral blood lymphocytes and peritoneal and spleen cells from vaccinated or protected animals can kill trophozoites of Entamoeba histolytica in vitro. In contrast, spleen cells from infected hamsters showed no significant cytotoxic effect on the parasite. These data suggest that cellular immunity plays an important role in host defense against hepatic amoebiasis.
摘要
对接种过疫苗或已免受肝阿米巴病侵害的仓鼠以及患有肝阿米巴病的仓鼠的外周血淋巴细胞、脾脏细胞和腹膜细胞的杀阿米巴活性进行了研究。来自接种过疫苗或已受保护动物的外周血淋巴细胞、腹膜细胞和脾脏细胞在体外可杀死溶组织内阿米巴滋养体。相比之下，感染仓鼠的脾脏细胞对该寄生虫未显示出明显的细胞毒性作用。这些数据表明，细胞免疫在宿主抵御肝阿米巴病中发挥着重要作用。
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本文引用的文献
1
THE TOXIC EFFECT OF ENTAMOEBA HISTOLYTICA ON LEUCOCYTES.溶组织内阿米巴对白细胞的毒性作用。
Ann Trop Med Parasitol. 1964 Sep;58:375-81. doi: 10.1080/00034983.1964.11686259.
2
Effect of immunosuppression on the size and metastasis of amoebic liver abscesses in hamsters.免疫抑制对仓鼠阿米巴肝脓肿大小和转移的影响。
Parasite Immunol. 1981 Winter;3(4):329-38. doi: 10.1111/j.1365-3024.1981.tb00411.x.
3
Protection against amebic liver abscess in hamsters by means of immunization with amebic antigen and some of its fractions.通过用阿米巴抗原及其部分组分进行免疫来预防仓鼠的阿米巴肝脓肿。
Am J Trop Med Hyg. 1980 Sep;29(5):779-84. doi: 10.4269/ajtmh.1980.29.779.
4
In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes.经特异性致敏的淋巴细胞在体外诱导巨噬细胞产生非特异性抵抗力。
Infect Immun. 1971 Oct;4(4):337-43. doi: 10.1128/iai.4.4.337-343.1971.
5
Trypanosoma lewisi: in vitro behavior of rat spleen cells.路氏锥虫：大鼠脾细胞的体外行为
Exp Parasitol. 1971 Dec;30(3):363-74. doi: 10.1016/0014-4894(71)90100-7.
6
Tumor cytotoxicity in vitro by macrophages from mice infected with mycobacterium bovis strain BCG.牛分枝杆菌卡介苗感染小鼠的巨噬细胞在体外的肿瘤细胞毒性
J Natl Cancer Inst. 1974 Jun;52(6):1887-95. doi: 10.1093/jnci/52.6.1887.
7
A role for activated macrophages in resistance to infection with Toxoplasma.活化巨噬细胞在抵抗弓形虫感染中的作用。
Infect Immun. 1972 Nov;6(5):829-34. doi: 10.1128/iai.6.5.829-834.1972.
8
Correlation of increased metabolic activity, resistance to infection, enhanced phagocytosis, and inhibition of bacterial growth by macrophages from Listeria- and BCG-infected mice.来自感染李斯特菌和卡介苗的小鼠的巨噬细胞的代谢活性增加、抗感染能力、吞噬作用增强以及对细菌生长的抑制作用之间的相关性。
Infect Immun. 1972 Apr;5(4):499-504. doi: 10.1128/iai.5.4.499-504.1972.
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Arch Invest Med (Mex). 1973:Suppl 1:141-6.
10
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Am J Trop Med Hyg. 1973 Nov;22(6):705-10. doi: 10.4269/ajtmh.1973.22.705.
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