二乙基二硫代氨基甲酸盐对人淋巴细胞的双相放射增敏作用：超氧化物歧化酶可能的参与

Biphasic radiosensitization of human lymphocytes by diethyldithiocarbamate: possible involvement of superoxide dismutase.

作者信息

Rigas D A, Eginitis-Rigas C, Bigley R H, Stankova L, Head C

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Sep;38(3):257-66. doi: 10.1080/09553008014551621.

Abstract

A biphasic radiosensitization of human lymphocytes by diethyldithiocarbamate (DDC), a metal chelator, was observed. The first phase occurred at 10(-5) M and the second at 10(-3) MDDC. The biphasic radiosensitization coincided with the previously reported biphasic toxicity of DDC. Inhibition of superoxide dismutase (SOD) occurred only in the second phase, suggesting that it may be a contributing cause of this phase. The mechanism of the first radiosensitization phase is not known. The radiation survival curves indicated the presence of at least two lymphocyte populations differing in their radiosensitivity and representing 40 per cent and 60 per cent of the cells. Both cell populations were biphasically radiosensitized by DDC.

摘要

观察到金属螯合剂二乙基二硫代氨基甲酸盐（DDC）对人淋巴细胞有双相放射增敏作用。第一相出现在10^(-5) M时，第二相出现在10^(-3) M DDC时。这种双相放射增敏作用与先前报道的DDC双相毒性一致。超氧化物歧化酶（SOD）的抑制仅发生在第二相，表明它可能是该相的一个促成原因。第一放射增敏相的机制尚不清楚。辐射存活曲线表明存在至少两个放射敏感性不同的淋巴细胞群体，分别占细胞的40%和60%。两个细胞群体均被DDC双相放射增敏。