Westman G, Midander J
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Jan;45(1):11-20. doi: 10.1080/09553008414550021.
The survival of Chinese hamster cells was reduced when they were temporarily treated with diethyldithiocarbamate (DDTC), an efficient inhibitor of CuZn superoxide dismutase (SOD), before radiation exposure. The dose-modifying factor amounted to about 1.3, and was the same for irradiation under hypoxic and aerobic conditions. Treatment of the cells with DDTC in the early post-irradiation hours was, however, equally effective. The results suggest that inhibition of CuZn SOD does not enhance the immediate radiation damage, but increases damage in the first hours of the post-irradiation period, possibly through mechanisms interfering with potential lethal damage.
在接受辐射之前，用二乙基二硫代氨基甲酸盐（DDTC，一种有效的铜锌超氧化物歧化酶（SOD）抑制剂）对中国仓鼠细胞进行短暂处理后，其存活率降低。剂量修正因子约为1.3，在缺氧和好氧条件下照射时相同。然而，在辐射后早期用DDTC处理细胞同样有效。结果表明，抑制铜锌超氧化物歧化酶不会增强即时辐射损伤，但会增加辐射后最初几个小时的损伤，可能是通过干扰潜在致死损伤的机制。
