Kent C, Blekkenhorst G
Research Institute for Medical Biophysics, Medical Research Council, Tygerberg, South Africa.
Free Radic Res Commun. 1991;12-13 Pt 2:595-9. doi: 10.3109/10715769109145835.
Superoxide dismutase (SOD) is known to protect cells from the lethal effects of ionizing radiation by the dismutation of oxygen radicals. Diethyldithiocarbamate (DDC) is known inhibitor of SOD and may therefore be useful as a radiosensitizer. DDC however, is also a thiol radioprotector due to its ability to scavenge radiation induced free radicals. We have shown that DDC, if administered to tumours 1 hour prior to x-irradiation exerts a protective effect, whereas if administered 4 hours prior to irradiation, it radiosensitizes. This time modulation effect is not apparent after neutron irradiation where DDC protects in both situations. We have also examined the effect of DDC on the LD50/30 in mice after total body irradiation.
超氧化物歧化酶（SOD）通过使氧自由基发生歧化反应来保护细胞免受电离辐射的致死效应。二乙基二硫代氨基甲酸盐（DDC）是已知的SOD抑制剂，因此可能用作放射增敏剂。然而，DDC由于能够清除辐射诱导的自由基，也是一种硫醇类辐射防护剂。我们已经表明，如果在X射线照射前1小时给肿瘤注射DDC，会产生保护作用，而如果在照射前4小时给药，则会起到放射增敏作用。在中子照射后，这种时间调制效应并不明显，DDC在两种情况下均起到保护作用。我们还研究了DDC对全身照射后小鼠LD50/30的影响。
