Burke J M
Invest Ophthalmol Vis Sci. 1981 Apr;20(4):435-41.
It was previously reported that injection of whole blood or hemoglobin into the rabbit vitreous is followed by two periods of immigration of phagocytic cells. The first period occurs within the first few days, and the second at round 3 weeks after experimental injury. In this report, invasive cells from these two periods after intravitreal hemoglobin injection were tested for their ability to release superoxide anion (O2). Levels of vitreal superoxide dismutase activity were also measured. The data indicate that cells of the second but not the first period of influx release excess O2. The cell-generated free radicals may contribute to vitreal liquefaction, although substantial liquefaction precedes the invasion of the second cell population. Since these cells can traverse adjacent tissues like the retina, they may also contribute by free radical production to the retinal injury that follows hemorrhage.
此前有报道称，向兔玻璃体注射全血或血红蛋白后，会有两个阶段的吞噬细胞移入。第一阶段发生在最初几天内，第二阶段在实验损伤后约3周时出现。在本报告中，对玻璃体内注射血红蛋白后这两个阶段的侵入细胞释放超氧阴离子（O2）的能力进行了测试。还测量了玻璃体中超氧化物歧化酶的活性水平。数据表明，第二阶段而非第一阶段流入的细胞会释放过量的O2。细胞产生的自由基可能导致玻璃体液化，尽管在第二群细胞侵入之前就已发生大量液化。由于这些细胞能够穿过相邻组织，如视网膜，它们也可能通过产生自由基导致出血后的视网膜损伤。
