McLean B, Holmes I H
J Clin Microbiol. 1980 Sep;12(3):320-5. doi: 10.1128/jcm.12.3.320-325.1980.
Levels of rotavirus-specific immunoglobulin G (IgG), IgA, IgM, and secretory immunoglobulin in maternal and cord serum, colostrum and milk, and infants' stools were measured by enzyme-linked immunosorbent assay in 92 mothers and their infants. Although antirotaviral IgG, IgA, and secretory immunoglobulin were present in most maternal sera, only IgG crossed the placenta. All samples of colostrum and milk tested contained antirotaviral secretory immunoglobulin and IgA except those of two women in whom IgA deficiency was subsequently described. Specific IgM and IgG were also detected in many colostral samples. Antirotaviral IgA was detected in many colostral samples. Antirotaviral IgA was detected in stools of breast-fed but not bottle-fed neonates. Apparently the human infant receives rotaviral antibodies both transplacentally and via maternal colostrum and milk.
通过酶联免疫吸附测定法,对92位母亲及其婴儿的母血和脐带血血清、初乳和乳汁以及婴儿粪便中的轮状病毒特异性免疫球蛋白G(IgG)、IgA、IgM和分泌型免疫球蛋白水平进行了检测。虽然大多数母血中存在抗轮状病毒IgG、IgA和分泌型免疫球蛋白,但只有IgG能穿过胎盘。除了随后被描述为存在IgA缺乏症的两名女性的样本外,所检测的所有初乳和乳汁样本均含有抗轮状病毒分泌型免疫球蛋白和IgA。在许多初乳样本中也检测到了特异性IgM和IgG。在母乳喂养而非人工喂养的新生儿粪便中检测到了抗轮状病毒IgA。显然,人类婴儿通过胎盘以及母体初乳和乳汁获得轮状病毒抗体。