Peplow P V, Hurst P R
Prostaglandins Med. 1981 Jan;6(1):29-39. doi: 10.1016/s0161-4630(81)80007-9.
In this study naproxen was released more rapidly than indomethacin from silastic rods in vitro, the periods of release being approximately 5 days and 20 days respectively. The release rate was dependent upon several factors including the initial concentration of the anti-inflammatory compound in the rod, the dimensions of the rods, and the pH of the buffer. Incorporation of albumin or fumed silica reduced only slightly the rate of release of indomethacin from the rods. The most significant way found for extending the period of release was to cover the silastic rods with a low permeability polyvinyl sleeve.
在本研究中，萘普生在体外从硅橡胶棒中的释放速度比吲哚美辛更快，释放期分别约为5天和20天。释放速率取决于几个因素，包括棒中抗炎化合物的初始浓度、棒的尺寸以及缓冲液的pH值。加入白蛋白或气相二氧化硅仅略微降低了吲哚美辛从棒中的释放速率。发现延长释放期的最有效方法是用低渗透性的聚乙烯套管覆盖硅橡胶棒。
