Hurst P R, Peplow P V
Contraception. 1985 May;31(5):445-52. doi: 10.1016/0010-7824(85)90080-0.
Studies were undertaken in rats to determine the intrauterine rate of release of high doses of indomethacin incorporated into Silastic rods. It was found that at a 28% w/w loading an 1X0.1 cm rod would exponentially deliver the drug at an average of 35 micrograms/day for the first 2 weeks; by 70 days the rate had declined to 6.5 microgram/day. After being present for 31 days, these types of medicated rods were found to reduce the numbers of luminal leukocytes when compared with the numbers obtained from uterine horns containing plain, non-medicated rods. Despite the reduction in leukocytosis, implantation was prevented by the high dose of indomethacin.
在大鼠身上进行了研究，以确定掺入硅橡胶棒中的高剂量吲哚美辛在子宫内的释放速率。结果发现，在28%（w/w）的负载量下，一根1×0.1厘米的棒在前两周内会以指数方式释放药物，平均每天释放35微克；到70天时，释放速率已降至每天6.5微克。在放置31天后，发现与含有普通非药物棒的子宫角相比，这些类型的药物棒可减少腔内白细胞数量。尽管白细胞增多有所减少，但高剂量的吲哚美辛仍会阻止着床。
