Suppression of leukocytosis by the intrauterine delivery of high doses of indomethacin in the rat.

Studies were undertaken in rats to determine the intrauterine rate of release of high doses of indomethacin incorporated into Silastic rods. It was found that at a 28% w/w loading an 1X0.1 cm rod would exponentially deliver the drug at an average of 35 micrograms/day for the first 2 weeks; by 70 days the rate had declined to 6.5 microgram/day. After being present for 31 days, these types of medicated rods were found to reduce the numbers of luminal leukocytes when compared with the numbers obtained from uterine horns containing plain, non-medicated rods. Despite the reduction in leukocytosis, implantation was prevented by the high dose of indomethacin.