Peplow P V, Hurst P R
Prostaglandins Med. 1981 Dec;7(6):563-9. doi: 10.1016/0161-4630(81)90046-x.
Rats with unilateral intrauterine silastic devices (made from 60 to 100 mg indomethacin/3 g silastic mixture) were found to have regular estrous cycles. No interference with body weight gain occurred in animals with the 100 mg/mix devices. The patterns of indomethacin release were dependent on the initial loading of the drug in the device, with the 60 and 100 mg/mix devices having delivery periods of approximately 50 days and 120 days respectively. Nevertheless, the absolute quantities of indomethacin delivered at any chosen time was remarkably similar for the two different loadings, suggesting that the properties of the external environment govern the total amount of drug released at specific times from these systems in utero.
使用单侧宫内硅橡胶装置（由60至100毫克吲哚美辛/3克硅橡胶混合物制成）的大鼠被发现具有规律的发情周期。使用100毫克/混合物装置的动物体重增加未受干扰。吲哚美辛的释放模式取决于装置中药物的初始装载量，60毫克/混合物和100毫克/混合物装置的释放期分别约为50天和120天。然而，两种不同装载量在任何选定时间递送的吲哚美辛绝对量非常相似，这表明外部环境的特性决定了这些子宫内系统在特定时间释放的药物总量。
