Braun E V, Ali M, Fayemi A O, Beaugard E
Cancer. 1981 Mar 15;47(6):1430-5. doi: 10.1002/1097-0142(19810315)47:6<1430::aid-cncr2820470631>3.0.co;2-w.
A case of primary signet-ring carcinoma of the urinary bladder treated with total cystectomy and clinically disease-free three years and nine months after surgery is described. The signet-ring cell carcinoma of the bladder is a rare neoplasm; among the five cases found in the literature, the neoplasms pursued a fulminant course, diffusely invaded the bladder wall without forming intraluminal growths, and could not be controlled by segmental resection, radiotherapy, and chemotherapy alone or in combinations. The pathogenesis of mucus-producing signet-ring cell carcinoma in the urinary bladder, an organ that normally contains no mucogenic elements, is discussed. The histologic evidence for the origin of this neoplasm from the totipotent urothelium is illustrated.
本文描述了一例原发性膀胱印戒细胞癌患者，该患者接受了全膀胱切除术，术后三年零九个月临床无病。膀胱印戒细胞癌是一种罕见的肿瘤；在文献报道的五例病例中，肿瘤进展迅速，弥漫性侵犯膀胱壁，未形成腔内肿物，单独或联合节段性切除、放疗及化疗均无法控制病情。本文还讨论了在正常情况下不含黏液生成成分的膀胱中产生黏液的印戒细胞癌的发病机制。文中展示了该肿瘤起源于全能尿路上皮的组织学证据。
