Sheldon G F, Sanders R, Fuchs R, Garcia J, Schooley J
Am J Surg. 1978 Mar;135(3):406-11. doi: 10.1016/0002-9610(78)90075-2.
The relationship between metabolism, oxygen transport, and anemia was assessed in burn patients. A significant negative correlation was found between erythrocyte 2,3 DPG, the major modulator of oxygen transport, and erythropoietin synthesis. Simultaneous bioassay and radioimmunoassay for erythropoietin revealed elevated values in the anemic burn patients. Elevated 2,3 DPG values during convalescence from thermal injury may remove the "anemic hypoxia" stimulus to erythropoieitn production, resulting in persistence of the anemia.
对烧伤患者的代谢、氧运输和贫血之间的关系进行了评估。发现氧运输的主要调节因子红细胞2,3-二磷酸甘油酸（2,3 DPG）与促红细胞生成素合成之间存在显著负相关。对促红细胞生成素进行的同步生物测定和放射免疫测定显示，贫血烧伤患者的值升高。热损伤恢复期2,3 DPG值升高可能会消除对促红细胞生成素产生的“贫血性缺氧”刺激，从而导致贫血持续存在。
