Melamed M R, Flehinger B J, Zaman M B, Heelan R T, Hallerman E T, Martini N
Cancer. 1981 Mar 1;47(5 Suppl):1182-7. doi: 10.1002/1097-0142(19810301)47:5+<1182::aid-cncr2820471322>3.0.co;2-4.
One-hundred-sixty-nine lung cancers have occurred to date among 10,040 cigarette smoking men who participated in the New York Lung Cancer Detection Program. Almost 40% of the cases, 65, were still Stage I when their disease was diagnosed; 62 had thoracotomy and resection, and in 57, mediastinal node dissection confirmed that the mediastinum was free of metastases ("true pathologic" Stage I). Fifty-four of the 62 (87%) are still alive at this time, while only 15 of 104 (14%) of those with Stage II and III lung cancers are alive. Only two patients of the 62 in Stage I who were treated by resection died of lung cancer, both with T2 tumors. Two others are alive with metastases, one died postoperatively, and five died of other causes without evidence of lung cancer. The estimated probability of survival for true Stage I lung cancer is over 90% at five years, and close to 40% of all lung cancers can be detected in this favorable stage by present radiologic and cytologic screening techniques.
在参与纽约肺癌检测项目的10040名吸烟男性中，迄今为止已发生169例肺癌。在这些病例中，近40%（65例）在疾病确诊时仍处于I期；62例行开胸手术及切除术，其中57例经纵隔淋巴结清扫证实纵隔无转移（“真正的病理”I期）。62例中的54例（87%）目前仍然存活，而II期和III期肺癌患者中104例仅有15例（14%）存活。I期接受切除术治疗的62例患者中，仅2例T2肿瘤患者死于肺癌。另外2例有转移灶的患者存活，1例术后死亡，5例死于其他原因，无肺癌证据。真正的I期肺癌患者五年生存率估计超过90%，通过目前的放射学和细胞学筛查技术，近40%的肺癌可在这个有利阶段被检测出来。
