动脉内注射顺铂治疗无法手术切除的骨骼肿瘤患者。

Intraarterial cis-platinum for patients with inoperable skeletal tumors.

作者信息

Mavligit G M, Benjamin R, Patt Y Z, Jaffe N, Chuang V, Wallace S, Murray J, Ayala A, Johnston S, Hersh E M, Calvo D B

出版信息

Cancer. 1981 Jul 1;48(1):1-4. doi: 10.1002/1097-0142(19810701)48:1<1::aid-cncr2820480102>3.0.co;2-r.

DOI:10.1002/1097-0142(19810701)48:1<1::aid-cncr2820480102>3.0.co;2-r

Abstract

Twenty-three patients with inoperable skeletal tumors were treated with intraarterial cis-platinum prior to attempted surgery. The antitumor effect of intraarterial cis-platinum was monitored clinically by radiologic imaging techniques, and whenever possible, evaluated histopathologically by examinatin of surgical or biopsy tumor specimens. Objective responses were noted in 12 patients (52%) and included 2 complete, 7 partial and 3 less-than-partial remissions lasting from 14 to 70 weeks. Limb-saving surgery or hemipelvectomy became subsequently feasible in four and one patients respectively. Preoperative intraarterial cis-platinum is a safe procedure which might be used effectively in combination with other, more conventioal postoperative adjuvant chemotherapy against skeletal tumors.

摘要

23例无法手术切除的骨骼肿瘤患者在尝试手术前接受了动脉内顺铂治疗。通过放射成像技术对动脉内顺铂的抗肿瘤效果进行临床监测，并尽可能通过手术或活检肿瘤标本的检查进行组织病理学评估。12例患者（52%）出现客观缓解，包括2例完全缓解、7例部分缓解和3例不完全缓解，缓解持续时间为14至70周。随后分别有4例和1例患者可行保肢手术或半骨盆切除术。术前动脉内顺铂治疗是一种安全的方法，可有效地与其他更传统的术后辅助化疗联合用于治疗骨骼肿瘤。