Wuisman P, Erlemann R, Roessner A, Bosse A, Kusniez-Glaz C
Department of Orthopaedics, Westfälischen Wilhelms University, Münster, Federal Republic of Germany.
Skeletal Radiol. 1991;20(4):294-8. doi: 10.1007/BF02341670.
A case is presented of an 18-year-old women who suffered pain and swelling after intraarterial cisplatin chemotherapy for osteosarcoma of the left fibula. Radiological studies showed minimal changes at the metadiaphyseal portion of the left tibia. Bone scans and MR studies were highly suggestive of necrosis of bone and muscle of the proximal end of the tibia. Multiple biopsies of the tibia at the time of excision and 2 years later showed histological features consistent with a slowly healing osteonecrosis of bone. Review of the literature reported transient pain and swelling after intraarterial chemotherapy but did not demonstrate the association with necrosis of bone and muscle. It can be anticipated that as intraarterial chemotherapy of malignant tumors of bone and soft tissues becomes more widely used, these complications will be observed more frequently.
本文报告了一例18岁女性患者，她在接受左腓骨骨肉瘤动脉内顺铂化疗后出现疼痛和肿胀。放射学研究显示左胫骨干骺端仅有轻微变化。骨扫描和磁共振成像研究高度提示胫骨近端骨和肌肉坏死。切除时及两年后对胫骨进行的多次活检显示组织学特征与骨坏死缓慢愈合一致。文献回顾报道动脉内化疗后有短暂疼痛和肿胀，但未显示与骨和肌肉坏死有关。可以预期，随着骨和软组织恶性肿瘤的动脉内化疗应用越来越广泛，这些并发症将更频繁地被观察到。
