Muirhead E E, Pitcock J A, Brown P S, Brooks B
Fed Proc. 1981 Jun;40(8):2262-7.
The kidney exerts both prohypertensive and antihypertensive functions. Part of the anti-hypertensive function of the kidney is mediated by the renomedullary interstitial cells (RIC), as an endocrine-type function. Six experimental models of hypertension and their relation to the antihypertensive function of the RIC are discussed. It is proposed that the anti-hypertensive function of the RIC may be deficient by the three mechanisms: 1) absence of the cells (as in the renoprival state); 2) severe damage to the cells (as in partial nephrectomy-salt hypertension of the rat and late malignant hypertension of the rabbit); and 3) constraint of the function of these cells (as in angiotensin-salt hypertension due to a lower salt intake). The constraint may result from excessive angiotensin, either by a direct effect or via a hemodynamic mechanism. The converting enzyme inhibitors (CEI) fail to exert their antihypertensive function when the RIC are absent or damaged. Conversely, the CEI are effective in those models associated with intact RIC. CEI appear to exert their antihypertensive action partly through an effect on RIC.
肾脏具有升压和降压两种功能。肾脏的部分降压功能是由肾髓质间质细胞（RIC）介导的，这是一种内分泌型功能。本文讨论了六种高血压实验模型及其与RIC降压功能的关系。研究表明，RIC的降压功能可能通过以下三种机制受损：1）细胞缺失（如肾缺如状态）；2）细胞严重受损（如大鼠部分肾切除-盐性高血压和兔晚期恶性高血压）；3）这些细胞的功能受限（如低盐摄入引起的血管紧张素-盐性高血压）。这种功能受限可能是由于血管紧张素过多，通过直接作用或血流动力学机制导致的。当RIC缺失或受损时，转换酶抑制剂（CEI）无法发挥其降压功能。相反，CEI在与完整RIC相关的模型中有效。CEI似乎部分通过对RIC的作用来发挥其降压作用。
