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水疱性口炎病毒RNA聚合酶在体外可通读前导基因和N基因之间的边界。

Vesicular stomatitis virus RNA polymerase can read through the boundary between the leader and N genes in vitro.

作者信息

Herman R C, Lazzarini R A

出版信息

J Virol. 1981 May;38(2):792-6. doi: 10.1128/JVI.38.2.792-796.1981.

DOI:10.1128/JVI.38.2.792-796.1981
PMID:6264146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171211/
Abstract

Triphosphorylated in vitro transcripts of vesicular stomatitis virus were selected by mercury-Sepharose chromatography using adenosine-5'-O-(3-thiotriphosphate) as an affinity probe. Numerous RNAs ranging from less than 47 up to several hundred nucleotides in length were detected. Some of these contain the leader RNA covalently linked to transcripts of the N gene. A comparison of the published genomic sequences at the estimated termination sites of several of these RNAs reveals some homology with the sequence present at both the end of the leader and polymerase genes.

摘要

使用腺苷-5'-O-(3-硫代三磷酸)作为亲和探针，通过汞-琼脂糖凝胶层析法筛选水泡性口炎病毒的三磷酸化体外转录本。检测到许多长度从小于47个核苷酸到数百个核苷酸不等的RNA。其中一些包含与N基因转录本共价连接的前导RNA。对其中几种RNA估计终止位点处已发表的基因组序列进行比较，发现与前导基因和聚合酶基因末端的序列存在一些同源性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b1/171211/eaecb19c3de9/jvirol00005-0394-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b1/171211/562c2a0725c3/jvirol00005-0393-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b1/171211/eaecb19c3de9/jvirol00005-0394-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b1/171211/562c2a0725c3/jvirol00005-0393-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b1/171211/eaecb19c3de9/jvirol00005-0394-a.jpg

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Vesicular stomatitis virus RNA polymerase can read through the boundary between the leader and N genes in vitro.水疱性口炎病毒RNA聚合酶在体外可通读前导基因和N基因之间的边界。
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2
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本文引用的文献

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Unique mode of transcription in vitro by Vesicular stomatitis virus.水疱性口炎病毒在体外的独特转录模式。
Cell. 1980 Aug;21(1):267-75. doi: 10.1016/0092-8674(80)90134-8.
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Site on the vesicular stomatitis virus genome specifying polyadenylation and the end of the L gene mRNA.水疱性口炎病毒基因组上指定多聚腺苷酸化及L基因mRNA末端的位点。
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In vitro synthesis of the full-length complement of the negative-strand genome RNA of vesicular stomatitis virus.水疱性口炎病毒负链基因组RNA全长互补序列的体外合成
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Aberrant glycoprotein mRNA synthesized by the internal deletion mutant of vesicular stomatitis virus.由水疱性口炎病毒内部缺失突变体合成的异常糖蛋白信使核糖核酸。
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Conditional synthesis of an aberrant glycoprotein mRNA by the internal deletion mutant of vesicular stomatitis virus.水泡性口炎病毒内部缺失突变体对异常糖蛋白mRNA的条件性合成。
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Transcription and replication of rhabdoviruses.弹状病毒的转录与复制
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7
Measles virus synthesizes both leaderless and leader-containing polyadenylated RNAs in vivo.麻疹病毒在体内合成无先导序列和含先导序列的多聚腺苷酸化RNA。
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Differential effect of ATP concentration on synthesis of vesicular stomatitis virus leader RNAs and mRNAs.ATP浓度对水疱性口炎病毒前导RNA和mRNA合成的差异影响。
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Complete intergenic and flanking gene sequences from the genome of vesicular stomatitis virus.水疱性口炎病毒基因组的完整基因间隔区及侧翼基因序列。
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Resolution of multiple ribonucleic acid species by polyacrylamide gel electrophoresis.通过聚丙烯酰胺凝胶电泳分离多种核糖核酸种类
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6
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Adenosine-5'-O-(3-thiotriphosphate) as an affinity probe for studying leader RNA's transcribed by vesicular stomatitis virus.
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