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水疱性口炎病毒钱迪普拉、科卡尔和皮里血清型基因组（+）前导RNA区域的序列测定。

Sequence determination of the (+) leader RNA regions of the vesicular stomatitis virus Chandipura, Cocal, and Piry serotype genomes.

作者信息

Giorgi C, Blumberg B, Kolakofsky D

出版信息

J Virol. 1983 Apr;46(1):125-30. doi: 10.1128/JVI.46.1.125-130.1983.

DOI:10.1128/JVI.46.1.125-130.1983
PMID:6298450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255099/
Abstract

Using 3'-end-labeled genome probes, cells infected with vesicular stomatitis virus Chandipura, Cocal, and Piry serotypes were shown to contain (+) leader RNAs of approximately 50 nucleotides in length. The nucleotide sequence of the leader RNA regions of these genomes was determined and compared with the previously reported sequences of both the (+) and (-) leader RNA regions of other vesicular stomatitis virus serotypes. Regions of strong conservation of nucleotide sequence among the various vesicular stomatitis virus serotypes suggest those nucleotides thought to be involved in control functions during vesicular stomatitis virus replication.

摘要

使用3'末端标记的基因组探针，研究发现感染水疱性口炎病毒钱迪普拉、科卡尔和皮里血清型的细胞含有长度约为50个核苷酸的(+)前导RNA。测定了这些基因组前导RNA区域的核苷酸序列，并与先前报道的其他水疱性口炎病毒血清型的(+)和(-)前导RNA区域的序列进行了比较。不同水疱性口炎病毒血清型之间核苷酸序列的高度保守区域表明，这些核苷酸被认为在水疱性口炎病毒复制过程中参与调控功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee0/255099/a9dafa155e07/jvirol00145-0138-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee0/255099/42a0cce6c0cf/jvirol00145-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee0/255099/dfe4bdf0d0ea/jvirol00145-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee0/255099/a9dafa155e07/jvirol00145-0138-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee0/255099/42a0cce6c0cf/jvirol00145-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee0/255099/dfe4bdf0d0ea/jvirol00145-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee0/255099/a9dafa155e07/jvirol00145-0138-a.jpg

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Sequence determination of the (+) leader RNA regions of the vesicular stomatitis virus Chandipura, Cocal, and Piry serotype genomes.水疱性口炎病毒钱迪普拉、科卡尔和皮里血清型基因组（+）前导RNA区域的序列测定。
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本文引用的文献

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N protein of vesicular stomatitis virus selectively encapsidates leader RNA in vitro.水疱性口炎病毒的N蛋白在体外选择性地包裹前导RNA。
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RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus.水疱性口炎病毒缺陷干扰颗粒模板启动子序列附近的RNA聚合酶相关相互作用。
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