Smolar N, Griffin B E
J Virol. 1981 Jun;38(3):958-67. doi: 10.1128/JVI.38.3.958-967.1981.
The DNA sequences of four "early" viable deletion mutants of polyoma virus have been determined. Two of these (dl-8 and dl-23) are mutants with deletions in the region of the genome that codes for parts of both large and middle T-antigens, and two (dl-6 and dl-28) are mutants with deletions around the viral origin of replication. The former mutants have altered transformation properties relative to wild-type virus, and dl-8 appears to be replication deficient (B. E. Griffin and C. Maddock, J. Virol. 31:645-656, 1979). Sequences are discussed in terms of the altered phenotypes observed for the various mutants, the DNA structures and protein sequences that are affected by the deletions, and how these might affect the biological properties of the mutants.
已测定了多瘤病毒四个“早期”存活缺失突变体的DNA序列。其中两个（dl-8和dl-23）是基因组中编码大T抗原和中T抗原部分区域发生缺失的突变体，另外两个（dl-6和dl-28）是病毒复制起点周围发生缺失的突变体。相对于野生型病毒，前一类突变体具有改变的转化特性，并且dl-8似乎复制缺陷（B.E.格里芬和C.马多克，《病毒学杂志》31:645 - 656，1979年）。根据观察到的各种突变体的表型改变、受缺失影响的DNA结构和蛋白质序列以及这些可能如何影响突变体的生物学特性来讨论序列。
