Cogen F C, Rigg G, Simmons J L, Domino E F
Ann Intern Med. 1978 Feb;88(2):210-2. doi: 10.7326/0003-4819-88-2-210.
Phencyclidine (PCP) is a dissociative veterinary anesthetic and tranquilizer that at present is being abused as a psychedelic and hallucinogenic agent with increasing frequency. The cases of two young patients suffering from phencyclidine toxicity are reported. In each, central nervous system depression was accompanied by an acute dystonic motor reaction resulting in acute rhabdomyolysis and myoglobinuria. Skeletal muscle injury was felt to be the result of excessive involuntary isometrimc motor activity rather than a direct effect of phencyclidine on skeletal muscle. Patients suffering from phencyclidine intoxication should be screened for acute rhabdomyolysis. Phencyclidine intoxication should be included in the differential of nontraumatic rhabdomyolysis and should be considered among the potential causes of acute myoglobinuric renal failure.
苯环己哌啶（PCP）是一种分离性兽用麻醉剂和镇静剂，目前正作为一种致幻剂被越来越频繁地滥用。本文报告了两例苯环己哌啶中毒的年轻患者病例。在每例患者中，中枢神经系统抑制均伴有急性张力障碍性运动反应，导致急性横纹肌溶解和肌红蛋白尿。骨骼肌损伤被认为是过度的非自主性等长运动活动所致，而非苯环己哌啶对骨骼肌的直接作用。苯环己哌啶中毒患者应进行急性横纹肌溶解筛查。苯环己哌啶中毒应列入非创伤性横纹肌溶解的鉴别诊断范围，并应被视为急性肌红蛋白尿性肾衰竭的潜在病因之一。
