梅毒螺旋体（Nichols株）中的质粒DNA：梅毒细菌产生抗生素耐药性的可能性。
Plasmid DNA in Treponema pallidum (Nichols): potential for antibiotic resistance by syphilis bacteria.
作者信息
Norgard M V, Miller J N
出版信息
Science. 1981 Jul 31;213(4507):553-5. doi: 10.1126/science.6264606.
PMID:6264606
Abstract
A plasmid DNA structure (approximate molecular weight = 7.5 X 10(6)) was identified in the human pathogen Treponema pallidum (Nichols). The inability to isolate this plasmid from rabbit host tissue and the total lack of DNA homology of the plasmid with rabbit DNA has confirmed its Treponema pallidum origin. The observation documents a newly recognized and potentially significant genetic capability for Treponema pallidum.
摘要
在人类病原体梅毒螺旋体（Nichols株）中鉴定出一种质粒DNA结构（近似分子量 = 7.5×10⁶）。无法从兔宿主组织中分离出该质粒，且该质粒与兔DNA完全缺乏DNA同源性，这证实了其梅毒螺旋体起源。该观察结果记录了梅毒螺旋体一种新认识到的且可能具有重要意义的遗传能力。
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