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乙醇对组胺敏感腺苷酸环化酶系统的体外效应。

The in vitro effect of ethanol on the histamine-sensitive adenylate cyclase system.

作者信息

Szücs M, Karnushina I

出版信息

Agents Actions. 1981 Apr;11(1-2):158-60. doi: 10.1007/BF01991488.

DOI:10.1007/BF01991488
PMID:6264763
Abstract

The effect of low concentrations (1-5%) of ethanol on the histamine-sensitive adenylate cyclase system was examined in guinea pig gastric mucosa and hippocampus homogenate. Ethanol in these concentrations caused a dose-dependent increase of the adenylate cyclase activity, and this effect was not inhibited by histamine antagonists. Phosphodiesterase activities were not affected by these concentrations of alcohol. Our in vitro findings agree well with the results of BUNCE and PARSONS [10].

摘要

在豚鼠胃黏膜和海马匀浆中检测了低浓度(1-5%)乙醇对组胺敏感的腺苷酸环化酶系统的影响。这些浓度的乙醇导致腺苷酸环化酶活性呈剂量依赖性增加,且这种效应不受组胺拮抗剂的抑制。这些浓度的酒精对磷酸二酯酶活性没有影响。我们的体外研究结果与邦斯和帕森斯[10]的结果非常一致。

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1
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引用本文的文献

1
Alcohol and gastric acid secretion in humans.酒精与人体胃酸分泌
Gut. 1993 Jun;34(6):843-7. doi: 10.1136/gut.34.6.843.
2
Effect of ethyl alcohol on the TSH-receptor-cyclase system in thyroid and nonthyroid tissues.乙醇对甲状腺及非甲状腺组织中促甲状腺激素受体-环化酶系统的影响。
World J Surg. 1986 Oct;10(5):787-96. doi: 10.1007/BF01655240.

本文引用的文献

1
Ethanol-stimulated acid secretion in the isolated whole stomach of the rat.乙醇刺激大鼠离体全胃的酸分泌。
J Pharm Pharmacol. 1980 Jan;32(1):45-8. doi: 10.1111/j.2042-7158.1980.tb12843.x.
2
Selective activation by short chain alcohols of glucagon responsive adenyl cyclase in liver.短链醇对肝脏中胰高血糖素反应性腺苷酸环化酶的选择性激活作用。
Endocrinology. 1970 Nov;87(5):1075-81. doi: 10.1210/endo-87-5-1075.
3
Effects of ethanol on gastric mucosal adenosine 3', 5' monophosphate (cAMP).乙醇对胃黏膜3',5'-环磷酸腺苷(cAMP)的影响。
Life Sci. 1974 Mar 16;14(6):1065-73. doi: 10.1016/0024-3205(74)90231-8.
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Stimulation of jejunal adenyl cyclase by ethanol.乙醇对空肠腺苷酸环化酶的刺激作用。
J Lab Clin Med. 1971 Sep;78(3):336-42.
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Multiple cyclic nucleotide phosphodiesterase activities from rat brain.大鼠脑中的多种环核苷酸磷酸二酯酶活性
Biochemistry. 1971 Jan 19;10(2):311-6.
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A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。
Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.
7
Cyclic nucleotide phosphodiesterases of human and rat gastric mucosa.人和大鼠胃黏膜的环核苷酸磷酸二酯酶
Naunyn Schmiedebergs Arch Pharmacol. 1977 Jan;296(2):187-90. doi: 10.1007/BF00508473.
8
Histamine-sensitive adenylate cyclase in mammalian brain.哺乳动物脑中的组胺敏感腺苷酸环化酶。
Nature. 1976 Mar 11;260(5547):163-5. doi: 10.1038/260163a0.