Heilmann H P, Doppelfeld E, Fernholz H J, Birkner R, Schlicker H, Becker G, Gordon-Harris L, Hackl A, Sager W D, Jentsch F, Kraft W, Bünemann H, Horstmann W, Hassenstein E, Kuttig H, Wieland C, Schmidt N, Müller A, Quäck J, Buchelt L, Hess F, Koop E A, von Lieven H, Heinze H G, Castrup W, Wannenmacher M, Rey G, Voss A C, Nüse A, Eibach E, Grund W, Bohndorf W, Schindler G
Dtsch Med Wochenschr. 1976 Oct 22;101(43):1557-62. doi: 10.1055/s-0028-1104302.
In a joint retrospective study by 17 radiotherapy clinics in German-speaking countries the results of treatment of bronchial carcinoma after radiotherapy were analysed in 7503 cases. The age peak was between the 60th and 70th year. Squamous-cell carcinoma was the most frequent histological type, followed by anaplastic carcinoma, with adenocarcinoma being rare. There was a high proportion of histologically not clearly identified cases (27% in central and 35% in peripheral carcinomas). Survival rate at one year was 31% for central (3662 patients) and peripheral (961 patients) tumours, but only 2% at five years. Prognostically there was no difference between histological types and kind of radiotherapy or technique, but total dose affected survival rate. At a total dose of less than 5000 rd the survival rate at five years was minimal. The prognosis of combined surgical and radiotherapeutic measures was slightly better than with a radiotherapy alone, but results were unpredictable for the individual case. It is concluded that radiotherapy aiming at cure should be used in imoperable bronchial carcinoma if the tumour state and general condition of the patient appear to make a cure possible. But if this is not the case, radiotherapy should be used only palliatively, i.e. only to ameliorate symptoms.
在德语国家17家放疗诊所开展的一项联合回顾性研究中，对7503例支气管癌放疗后的治疗结果进行了分析。年龄高峰在60至70岁之间。鳞状细胞癌是最常见的组织学类型，其次是间变性癌，腺癌较为少见。组织学上未明确诊断的病例比例较高（中央型癌为27%，周围型癌为35%）。中央型肿瘤（3662例患者）和周围型肿瘤（961例患者）的一年生存率为31%，但五年生存率仅为2%。在预后方面，组织学类型、放疗种类或技术之间没有差异，但总剂量会影响生存率。总剂量低于5000拉德时，五年生存率极低。手术与放疗联合治疗的预后略优于单纯放疗，但对个别病例而言结果难以预测。结论是，如果肿瘤状况和患者一般状况显示有可能治愈，对于无法手术的支气管癌应采用旨在治愈的放疗。但如果情况并非如此，放疗仅应采用姑息性方式，即仅用于缓解症状。
