缺乏3',5'-环磷酸腺苷系统的大肠杆菌K-12突变体对美西林的敏感性
Mecillinam susceptibility of Escherichia coli K-12 mutants deficient in the adenosine 3',5'-monophosphate system.
作者信息
Scott N W, Harwood C R
出版信息
Antimicrob Agents Chemother. 1981 Apr;19(4):540-4. doi: 10.1128/AAC.19.4.540.
Abstract
The mecillinam resistance of Escherichia coli K-12 mutants deficient in the enzyme responsible for the synthesis of adenosine 3',5'-monophosphate, adenylate cyclase, has been investigated. The results suggest that resistance to this antibiotic may be a consequence of the slow growth rate of these mutants rather than an intrinsic property of their genetic lesion.
摘要
对缺乏负责合成3',5'-单磷酸腺苷（腺苷酸环化酶）的酶的大肠杆菌K-12突变体对美西林的耐药性进行了研究。结果表明，对这种抗生素的耐药性可能是这些突变体生长速率缓慢的结果，而不是其基因损伤的固有特性。
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