大肠杆菌对美西林耐药的圆形形态突变体的定位
Mapping of the mecillinam-resistant, round morphological mutants of Escherichia coli.
作者信息
Iwaya M, Jones C W, Khorana J, Strominger J L
出版信息
J Bacteriol. 1978 Jan;133(1):196-202. doi: 10.1128/jb.133.1.196-202.1978.
Abstract
Genes responsible for round morphology in mecillinam-resistant, round morphological mutants of Escherichia coli have been mapped. Three mutants, called rodX, mapped at around 14 min, and two, called rodY, mapped at around 70 min by P1 transduction. These are either the same or very close to the loci reported, respectively, for the rodA (H. Matsuzawa, K. Hayakawa, T. Sato, and K. Imahori, J. Bacteriol. 115:436-442, 1973) and envB genes (B. Westling-Häggström and S. Normark, J. Bacteriol. 123:75-82, 1975). This suggests that mecillinam can be used very efficiently to select for found morphological mutants of rodA and envB after nitrosoguanidine treatment.
摘要
已对负责大肠杆菌耐美西林圆形形态突变体中圆形形态的基因进行了定位。通过P1转导，三个名为rodX的突变体定位在约14分钟处，两个名为rodY的突变体定位在约70分钟处。这些位点分别与已报道的rodA基因（H. Matsuzawa、K. Hayakawa、T. Sato和K. Imahori，《细菌学杂志》115:436 - 442，1973年）和envB基因（B. Westling-Häggström和S. Normark，《细菌学杂志》123:75 - 82，1975年）相同或非常接近。这表明美西林可非常有效地用于在亚硝基胍处理后筛选rodA和envB的形态突变体。
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