感染单纯疱疹病毒的小鼠的耐受性和免疫：对迟发型超敏反应耐受性机制的研究。
Tolerance and immunity in mice infected with herpes simplex virus: studies on the mechanism of tolerance to delayed-type hypersensitivity.
作者信息
Nash A A, Phelan J, Gell P G, Wildy P
出版信息
Immunology. 1981 Jun;43(2):363-9.
Abstract
Tolerance to delayed-type hypersensitivity is produced in mice following an intravenous injection of herpes simplex virus. This form of tolerance is produced early on, following simultaneous injections of virus subcutaneously and intravenously, and is long lasting (greater than 100 days). The early tolerance mechanism is resistant to high doses of cyclophosphamide and is not transferable by serum or spleen cells taken after 7 days. However, spleen cells taken at 14 days onwards inhibit the induction of delayed hypersensitivity when transferred to normal syngeneic recipients. These cells are T lymphocytes and are specific for the herpes type used in the induction.
摘要
给小鼠静脉注射单纯疱疹病毒后可产生对迟发型超敏反应的耐受性。这种耐受性在同时皮下和静脉注射病毒后早期即可产生，且持续时间长（超过100天）。早期耐受机制对高剂量环磷酰胺具有抗性，且7天后获取的血清或脾细胞无法传递这种耐受性。然而，14天及以后获取的脾细胞转移至正常同基因受体时会抑制迟发型超敏反应的诱导。这些细胞是T淋巴细胞，对诱导过程中使用的疱疹病毒类型具有特异性。
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