对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞反应。V. 独特型在抑制途径中的作用。
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway.
作者信息
Weinberger J Z, Germain R N, Benacerraf B, Dorf M E
出版信息
J Exp Med. 1980 Jul 1;152(1):161-9. doi: 10.1084/jem.152.1.161.
Abstract
4-Hydroxy-3-nitrophenyl (NP) derivatized syngeneic spleen cells injected intravenously stimulate maturation of an antigen-binding, idiotype-bearing induction-phase suppressor cell population, as well as an idiotype-binding anti-idiotype-bearing effector-phase suppressor cell population. Both cell types are present simultaneously in the spleen cell population 7-d after their induction. Furthermore, the cell population with antigen-binding properties can, in the presence of NP-derivatized syngeneic cells, induce a population of effector suppressor cells. The precursors of the effector suppressor population are not sensitive to concentrations of cyclophosphamide which prevented the generation of induction phase suppressor cells. These data provide direct evidence in support of the theory of network regulation of immune suppression. X
摘要
静脉注射4-羟基-3-硝基苯基（NP）衍生的同基因脾细胞可刺激具有抗原结合能力、携带独特型的诱导期抑制性细胞群体以及携带独特型结合抗独特型的效应期抑制性细胞群体的成熟。这两种细胞类型在诱导后7天同时存在于脾细胞群体中。此外，具有抗原结合特性的细胞群体在NP衍生的同基因细胞存在的情况下，可诱导效应性抑制细胞群体的产生。效应性抑制细胞群体的前体细胞对环磷酰胺浓度不敏感，而环磷酰胺浓度可阻止诱导期抑制细胞的产生。这些数据为免疫抑制的网络调节理论提供了直接证据。X
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本文引用的文献
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Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
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2
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Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
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Production of large amounts of antibodies in individual mice.在个体小鼠中产生大量抗体。
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Idiotype suppression. III. Induction of unresponsiveness to sensitization with anti-idiotypic antibody: identification of the cell types tolerized in high zone and in low zone, suppressor cell-mediated, idiotype suppression.
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Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor.小鼠对2,4-二硝基氟苯耐受性和接触敏感性中的可溶性因子。III. 与半抗原二硝基苯酚相关的组织相容性抗原作为2,4-二硝基氟苯免疫T细胞上可溶性抑制因子的靶分子。
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