Makarov V A, Manuĭlov I D
Farmakol Toksikol. 1978 Mar-Apr;41(2):212-4.
By using the "turned inside out bag" technique and brough tests with homogenates it was found that sulfanilamide is susceptible to acetylation in a larger measure than sulfocarbamide and sulfacylum natrium. In tests with isolated lengths of the small intestine phenobarbital (in doses of 25 mg/kg for 5 days) weakened acetylation of sulfanilamide and sulfocarbamide and did not change acetylation of sulfacylum natrium. Acetylation of all these three sulfanilamides in homogenates of the liver, blood and the small intestine mucosa did not change under the effect of phenobarbital.
通过使用“外翻袋”技术并对匀浆进行相关测试发现，磺胺比磺胺脲和磺胺醋酰钠更易发生乙酰化。在对分离的小肠段进行的测试中，苯巴比妥（剂量为25毫克/千克，持续5天）减弱了磺胺和磺胺脲的乙酰化，而对磺胺醋酰钠的乙酰化没有影响。在苯巴比妥的作用下，肝脏、血液和小肠黏膜匀浆中这三种磺胺的乙酰化均未发生变化。
