Baraka A
Br J Anaesth. 1978 Feb;50(2):195-9. doi: 10.1093/bja/50.2.195.
The effects of the systemic and of the i.v. regional administration of suxamethonium were investigated in 23 patients with traumatic nerve injury. Following the systemic administration of suxamethonium 100 mg, normally innervated muscles showed muscle fasciculations initially, followed by muscular relaxation. On the other hand, denervated muscles did not fasciculate and, in 21 patients, manifested suxamethonium-induced contractures. In the other two patients no response was observed. In 10 of the patients, the i.v. regional administration of suxamethonium 5 mg was followed by a contracture of the denervated muscle which was maintained until the tourniquet was deflated. No systemic reaction to suxamethonium, other than mild ptosis, followed the release of the tourniquet.
在23例创伤性神经损伤患者中研究了琥珀胆碱全身给药和静脉区域给药的效果。静脉注射100mg琥珀胆碱后，正常支配的肌肉最初出现肌束颤动，随后肌肉松弛。另一方面，失神经支配的肌肉不出现肌束颤动，并且在21例患者中表现出琥珀胆碱诱导的挛缩。另外2例患者未观察到反应。在10例患者中，静脉区域注射5mg琥珀胆碱后，失神经支配的肌肉出现挛缩，这种挛缩一直持续到松开止血带。松开止血带后，除了轻度上睑下垂外，未出现对琥珀胆碱的全身反应。
