Ford-Hutchinson A W, Bray M A, Smith M J
Agents Actions. 1980 Dec;10(6):548-50. doi: 10.1007/BF02024162.
Polymorphonuclear leucocytes (PMNs), when exposed to the calcium ionophore A23178, release into the supernatant a substance that causes the aggregation and chemokinesis of fresh PMN suspensions. Release of these activities is inhibited by preincubation with drugs known to inhibit lipoxygenase pathways of arachidonic acid metabolism but is unaffected by cyclooxygenase inhibitors. The substance responsible for these activities has been identified as leukotriene B and this compound has been shown to be a potent chemokinetic and aggregatory agent for PMNs over the range 10 pg to 5 ng ml-1.
多形核白细胞（PMNs）在暴露于钙离子载体A23178时，会将一种导致新鲜PMN悬浮液聚集和化学趋化的物质释放到上清液中。已知抑制花生四烯酸代谢的脂氧合酶途径的药物预孵育可抑制这些活性的释放，但不受环氧化酶抑制剂的影响。负责这些活性的物质已被鉴定为白三烯B，并且已证明该化合物在10 pg至5 ng ml-1范围内是一种有效的PMN化学趋化剂和聚集剂。
