12-L-羟基-5,8,10,14-二十碳四烯酸对人嗜酸性粒细胞和中性粒细胞多形核白细胞趋化性及随机迁移的刺激作用。
Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.
作者信息
Goetzl E J, Woods J M, Gorman R R
出版信息
J Clin Invest. 1977 Jan;59(1):179-83. doi: 10.1172/JCI108617.
Abstract
A human platelet lipoxygenase-generated product of arachidonic acid, identified by thin-layer chromatographic and mass spectrometric properties as 12-L-hydroxy-5,8,10,14-eicosatertraenoic acid (HETE), was selectively chemotactic in vitro for human polymorphonuclear leukocytes (PMN), as compared to mononuclear leukocytes, with a preference for eosinophils. Preincubation of PMN with partially-purified HETE at peak chemotactic concentrations of 8-24 mug/ml reduced their random and chemotactic migration and stimulated the activity of their hexose monophosphate shunt; minimally chemotactic concentrations of 0.03-1 mug/ml enhanced PMN random migration without influencing other functions. HETE may thus be capable of preferentially attracting eosinophils to foci of tissue reaction associated with platelet activation.
摘要
一种由人血小板脂氧合酶生成的花生四烯酸产物，通过薄层色谱和质谱特性鉴定为12-L-羟基-5,8,10,14-二十碳四烯酸（HETE），与单核白细胞相比，它在体外对人多形核白细胞（PMN）具有选择性趋化作用，对嗜酸性粒细胞更具偏好性。用部分纯化的HETE在8 - 24微克/毫升的峰值趋化浓度下对PMN进行预孵育，可降低其随机迁移和趋化迁移，并刺激其磷酸己糖旁路的活性；0.03 - 1微克/毫升的最低趋化浓度可增强PMN的随机迁移，而不影响其他功能。因此，HETE可能能够优先将嗜酸性粒细胞吸引到与血小板活化相关的组织反应部位。
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