通道门控聚集模型预测的钠电导系统中的新动力学。
Novel kinetics in the sodium conductance system predicted by the aggregation model of channel gating.
作者信息
Baumann G
出版信息
Biophys J. 1981 Sep;35(3):699-705. doi: 10.1016/S0006-3495(81)84821-7.
Abstract
Special voltage-clamp pulse protocols are given that make differential predictions for the kinetics of models based on a simple sequential, simple cyclic, and an aggregation scheme. Detailed kinetic time-courses for the discriminating pulse protocols are numerically derived from the differential equation system that describes the aggregation model.
摘要
给出了特殊的电压钳脉冲协议，这些协议对基于简单顺序、简单循环和聚集方案的模型动力学做出了不同的预测。用于区分的脉冲协议的详细动力学时间进程是从描述聚集模型的微分方程系统中数值推导出来的。
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本文引用的文献
1
A quantitative description of membrane current and its application to conduction and excitation in nerve.
J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
2
Experimental evidence consistent with aggregation kinetics in the sodium current of Myxicola giant axons.
Biophys J. 1981 Sep;35(3):707-14. doi: 10.1016/S0006-3495(81)84822-9.
3
Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons.
J Gen Physiol. 1969 Nov;54(5):553-75. doi: 10.1085/jgp.54.5.553.
4
On the theory of ion transport across the nerve membrane. 3. Potassium ion kinetics and cooperativity (with x=4,6,9).
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2488-92. doi: 10.1073/pnas.68.10.2488.
5
Kinetics of channel gating in excitable membranes.
Q Rev Biophys. 1976 Nov;9(4):491-526. doi: 10.1017/s0033583500002651.
6
Inactivation of the sodium channel. II. Gating current experiments.
J Gen Physiol. 1977 Nov;70(5):567-90. doi: 10.1085/jgp.70.5.567.
7
Inactivation of the sodium channel. I. Sodium current experiments.
J Gen Physiol. 1977 Nov;70(5):549-66. doi: 10.1085/jgp.70.5.549.
8
Fast and slow steps in the activation of sodium channels.
J Gen Physiol. 1979 Dec;74(6):691-711. doi: 10.1085/jgp.74.6.691.
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