Mironov S L
Department of Neurophysiology, Max-Planck-Institute for Psychiatry, Planegg-Martinsried, Germany.
Biophys J. 1992 Aug;63(2):485-96. doi: 10.1016/S0006-3495(92)81628-4.
The permeation properties of ion channels existing in several conductive states were analyzed. Each state was represented by the one-ion model. A special emphasis was placed on features, assumed to be indicative of a multi-ion mode of channel occupancy such as a deviation of concentration dependence of channel conductance from the Michaelis-Menten equation, an anomalous mole fraction effect, a strong voltage dependence of ion block and coupling of unidirectional fluxes (anomalous Ussing flux ratio). The conformational model was shown to have all these properties. The ion permeation through voltage-sensitive calcium channels fulfilled all the characteristics of the model proposed.
分析了处于几种导电状态的离子通道的渗透特性。每种状态均由单离子模型表示。特别强调了一些特征，这些特征被认为表明通道占据的多离子模式，例如通道电导的浓度依赖性偏离米氏方程、异常摩尔分数效应、离子阻断的强电压依赖性以及单向通量的耦合（异常乌斯辛通量比）。构象模型显示具有所有这些特性。电压敏感性钙通道的离子渗透符合所提出模型的所有特征。
