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1
Experimental evidence consistent with aggregation kinetics in the sodium current of Myxicola giant axons.与黏液虫巨大轴突钠电流中的聚集动力学一致的实验证据。
Biophys J. 1981 Sep;35(3):707-14. doi: 10.1016/S0006-3495(81)84822-9.
2
Initial conditions and the kinetics of the sodium conductance in Myxicola giant axons. I. effects on the time-course of the sodium conductance.黏液虫巨型轴突中钠电导的初始条件及动力学。I. 对钠电导时间进程的影响
J Gen Physiol. 1978 Dec;72(6):863-77. doi: 10.1085/jgp.72.6.863.
3
Inactivation in Myxicola giant axons responsible for slow and accumulative adaptation phenomena.黏液虫巨大轴突中的失活与缓慢累积适应现象有关。
J Physiol. 1981 Mar;312:531-49. doi: 10.1113/jphysiol.1981.sp013642.
4
Modifications of sodium channel gating in Myxicola giant axons by deuterium oxide, temperature, and internal cations.氧化氘、温度和内部阳离子对Myxicola巨轴突中钠通道门控的修饰作用。
Biophys J. 1979 Aug;27(2):193-208. doi: 10.1016/S0006-3495(79)85211-X.
5
Amino acid transport in Myxicola giant axon: stability of the amino acid pool, taurine efflux, and trans effect of sodium.黏液虫巨大轴突中的氨基酸转运：氨基酸库的稳定性、牛磺酸外流及钠的转位效应
J Physiol. 1981 Aug;317:103-27. doi: 10.1113/jphysiol.1981.sp013816.
6
An ion-site interaction model for sodium currents in the giant axon.巨轴突中钠电流的离子位点相互作用模型。
Biophys Chem. 1984 Nov;20(4):285-98. doi: 10.1016/0301-4622(84)80019-8.
7
Sensitivity of the sodium and potassium channels of Myxicola giant axons to changes in external pH.黏液虫巨型轴突的钠通道和钾通道对细胞外pH变化的敏感性。
J Gen Physiol. 1976 Feb;67(2):185-95. doi: 10.1085/jgp.67.2.185.
8
Dendrotoxin blocks potassium channels and slows sodium inactivation in Myxicola giant axons.树眼镜蛇毒素可阻断钾通道，并减缓黏液虫巨型轴突中的钠失活。
J Pharmacol Exp Ther. 1987 Jun;241(3):793-6.
9
Characteristics of sodium tail currents in Myxicola axons. Comparison with membrane asymmetry currents.黏液虫轴突中钠尾电流的特征。与膜不对称电流的比较。
Biophys J. 1977 Jul;19(1):7-28. doi: 10.1016/S0006-3495(77)85559-8.
10
Insensitivity of activation delays in potassium and sodium channels to heavy water in Myxicola giant axons.黏液虫巨大轴突中钾离子和钠离子通道激活延迟对重水不敏感。
J Physiol. 1983 Apr;337:173-82. doi: 10.1113/jphysiol.1983.sp014618.

引用本文的文献

1
Rapid sodium channel conductance changes during voltage clamp steps in squid giant axons.在乌贼巨大轴突电压钳制步骤期间快速钠通道电导的变化。
Biophys J. 1984 Mar;45(3):513-21. doi: 10.1016/S0006-3495(84)84188-0.
2
Novel kinetics in the sodium conductance system predicted by the aggregation model of channel gating.通道门控聚集模型预测的钠电导系统中的新动力学。
Biophys J. 1981 Sep;35(3):699-705. doi: 10.1016/S0006-3495(81)84821-7.

本文引用的文献

1
A quantitative description of membrane current and its application to conduction and excitation in nerve.膜电流的定量描述及其在神经传导和兴奋中的应用。
J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
2
Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process.黏液虫巨型轴突中钠电流的失活。与激活过程偶联的证据。
J Gen Physiol. 1972 Jun;59(6):659-75. doi: 10.1085/jgp.59.6.659.
3
Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons.黏液虫巨型轴突中钠电流和钾电流的定量描述及计算动作电位
J Gen Physiol. 1973 Mar;61(3):361-84. doi: 10.1085/jgp.61.3.361.
4
A molecular model of membrane excitability.膜兴奋性的分子模型。
J Supramol Struct. 1974;2(5-6):538-57. doi: 10.1002/jss.400020504.
5
Determination of the resistance in series with the membranes of giant axons.
J Membr Biol. 1975 Apr 23;21(1-2):25-47. doi: 10.1007/BF01941060.
6
Activation-inactivation coupling in Myxicola giant axons injected with tetraethylammonium.注射四乙铵的Myxicola巨轴突中的激活-失活偶联
Biophys J. 1976 Sep;16(9):985-9. doi: 10.1016/S0006-3495(76)85749-9.
7
Characteristics of sodium tail currents in Myxicola axons. Comparison with membrane asymmetry currents.黏液虫轴突中钠尾电流的特征。与膜不对称电流的比较。
Biophys J. 1977 Jul;19(1):7-28. doi: 10.1016/S0006-3495(77)85559-8.
8
Combined voltage-clamp and dialysis of Myxicola axons: behaviour of membrane asymmetry currents.混合电压钳制与对黏液虫轴突的透析：膜不对称电流的行为
J Physiol. 1978 May;278:309-24. doi: 10.1113/jphysiol.1978.sp012306.
9
Inactivation of the sodium channel. II. Gating current experiments.钠通道的失活。II. 门控电流实验。
J Gen Physiol. 1977 Nov;70(5):567-90. doi: 10.1085/jgp.70.5.567.
10
Fast and slow steps in the activation of sodium channels.钠通道激活过程中的快步骤和慢步骤。
J Gen Physiol. 1979 Dec;74(6):691-711. doi: 10.1085/jgp.74.6.691.

与黏液虫巨大轴突钠电流中的聚集动力学一致的实验证据。

Experimental evidence consistent with aggregation kinetics in the sodium current of Myxicola giant axons.

作者信息

Schauf C L, Baumann G

出版信息

Biophys J. 1981 Sep;35(3):707-14. doi: 10.1016/S0006-3495(81)84822-9.

DOI:10.1016/S0006-3495(81)84822-9
PMID:6897937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1327558/
Abstract

Aggregation kinetics, in contrast to the Hodgkin-Huxley equations, predict that if an axon is subjected to a brief perturbing depolarization of large amplitude, the resulting perturbed current will cross over the response to a conventional maintained depolarization, and then remain smaller for the remainder of the depolarizing step. This has been experimentally tested using voltage-clamped Myxicola giant axons, compensated for series resistance and bathed in 10% Na+ sea water to minimize possible artifacts. Under such conditions perturbed and unperturbed currents are observed to cross over in a manner qualitatively consistent with the behavior predicted by an aggregation model. We suggest, therefore, that the aggregation concept may warrant further experimental and theoretical investigation.

摘要

与霍奇金-赫胥黎方程不同，聚合动力学预测，如果轴突受到大幅度的短暂扰动去极化，那么由此产生的扰动电流将超过对传统持续去极化的响应，然后在去极化步骤的剩余时间内保持较小。这已经通过对电压钳制的黏液虫巨型轴突进行实验测试，对串联电阻进行了补偿，并浸泡在10%的Na+海水中以尽量减少可能的假象。在这种条件下，观察到扰动电流和未扰动电流以一种与聚合模型预测行为定性一致的方式交叉。因此，我们认为聚合概念可能值得进一步的实验和理论研究。