Rubinow D R, Post R M, Pickar D, Naber D, Ballenger J C, Gold P W, Bunney W E
Psychiatry Res. 1981 Aug;5(1):87-93. doi: 10.1016/0165-1781(81)90064-0.
We investigated the relationship between hypothalamic-pituitary-adrenal (HPA) activity, as measured by 24-hour mean urinary free cortisol (MUFC), and cerebrospinal fluid (CSF) opioid activity in patients with major affective disorder and normal volunteers. Among depressed patients, but not normal volunteers, mean 24-hour urinary cortisol values were significantly correlated with CSF opioid activity measured by radioreceptor assay, but were not significantly correlated with beta-endorphin immunoreactivity measured by radioimmunoassay. MUFC, as expected, was significantly higher in depressed patients than in normal volunteers. Mean values of CSF opioid activity and beta-endorphin immunoreactivity did not differ significantly in the two groups. The positive opioid-MUFC correlation found in the depressed group appeared to depend on patients who were cortisol hypersecretors. These data, using relatively crude measures of cortisol and opioid activity, are suggestive of a relationship between these two systems, particularly under "activated" conditions such as those observed in depression.
我们研究了重度情感障碍患者和正常志愿者中，通过24小时平均尿游离皮质醇（MUFC）测量的下丘脑-垂体-肾上腺（HPA）活性与脑脊液（CSF）阿片样物质活性之间的关系。在抑郁症患者而非正常志愿者中，24小时平均尿皮质醇值与通过放射受体测定法测得的脑脊液阿片样物质活性显著相关，但与通过放射免疫测定法测得的β-内啡肽免疫反应性无显著相关性。正如预期的那样，抑郁症患者的MUFC显著高于正常志愿者。两组脑脊液阿片样物质活性和β-内啡肽免疫反应性的平均值无显著差异。抑郁症组中发现的阿片样物质与MUFC的正相关似乎取决于皮质醇分泌过多的患者。这些使用相对粗略的皮质醇和阿片样物质活性测量方法的数据表明，这两个系统之间存在关系，特别是在“激活”状态下，如在抑郁症中观察到的情况。
