Tielen M J, van Exsel A C, Brus D H, Truijen W T
Tijdschr Diergeneeskd. 1981 Aug 1;106(15):739-47.
Trials were made to study the extent to which 6-10-week-old piglets with and without virus-neutralizing (VN) antibodies are capable of a serological response to vaccination. The piglets were inoculated with three different vaccines: two live vaccines (Aescovac Aujeszky and MK25 vaccine) and an inactivated vaccine (Geskyvac). The titre of virus-neutralizing antibody in the blood was determined for each vaccine in approximately 200 piglets at the time of inoculation as well as within four and twelve weeks after inoculation. The maternal antibodies present at the time of inoculation were found to have an inhibitory action on the serological response following inoculation. Of those piglets in which a maternal VN titre was observed using the above technique, only 9 per cent showed an increase in titre after inoculation. This proportion was 74 per cent in the serologically negative piglets. Marked variations in serological response to the different vaccines were observed. the most positive response was that induced by Aescovac. There was an obvious relationship between the VN titre following inoculation and immunity against intracerebral challenge with 2,000 TCID50 of Aujeszky disease virus. Animals showing titres of 1:4 or over were immune to this challenge.
开展试验以研究6至10周龄有或没有病毒中和（VN）抗体的仔猪对疫苗接种产生血清学反应的程度。给仔猪接种三种不同的疫苗：两种活疫苗（Aescovac Aujeszky疫苗和MK25疫苗）和一种灭活疫苗（Geskyvac疫苗）。在接种时以及接种后四周和十二周，测定约200头仔猪中每种疫苗接种后血液中的病毒中和抗体效价。发现接种时存在的母源抗体对接种后的血清学反应有抑制作用。在使用上述技术观察到母源VN效价的仔猪中，只有9%在接种后效价升高。在血清学阴性的仔猪中，这一比例为74%。观察到对不同疫苗的血清学反应存在明显差异。最积极的反应是由Aescovac疫苗诱导的。接种后的VN效价与针对2000个半数组织培养感染剂量（TCID50）的奥耶斯基病病毒脑内攻毒的免疫力之间存在明显关系。效价达到1:4或更高的动物对这种攻毒具有免疫力。
