Goldsmith M, Koutcher J, Damadian R
Cancer. 1978 Jan;41(1):183-91. doi: 10.1002/1097-0142(197801)41:1<183::aid-cncr2820410127>3.0.co;2-1.
One hundred two specimens of human gastro-intestinal tissue taken from eighty-seven individuals were inspected by proton magnetic resonance techniques (at 22.5 Megahertz). The purpose of the study was to evaluate the diagnostic capabilities of the nuclear magnetic resonance (NMR) technique with regard to the diagnosis of malignancy. The combination of two NMR parameters (spin-lattice ((T1) and spin-spin ((T2)) relaxation times) into a malignancy index yielded complete discrimination between the two populations of tissue. The mean and standard deviations obtained were 2.004 +/- 0.342 for normal tissue, and 3.266 +/- 0.642 for malignant specimens. In addition, the NMR technique indicated that histologically normal tissue taken adjacent to the malignancy was pathologically "involved". Analysis of the electrolyte and water content of such tissues confirms this abnormality.
采用质子磁共振技术（22.5兆赫）对取自87名个体的102份人体胃肠道组织样本进行了检查。本研究的目的是评估核磁共振（NMR）技术在恶性肿瘤诊断方面的诊断能力。将两个NMR参数（自旋晶格（T1）和自旋 - 自旋（T2）弛豫时间）组合成一个恶性肿瘤指数，可对两组组织进行完全区分。正常组织的平均值和标准差分别为2.004±0.342，恶性样本的平均值和标准差分别为3.266±0.642。此外，NMR技术表明，取自恶性肿瘤附近的组织学上正常的组织在病理上已“受累”。对此类组织的电解质和水分含量分析证实了这种异常情况。
