Santhana Mariappan S V, Subramanian S, Chandrakumar N, Rajalakshmi K R, Sukumaran S S
Department of Chemistry, Indian Institute of Technology, Madras.
Magn Reson Med. 1988 Oct;8(2):119-28. doi: 10.1002/mrm.1910080202.
Proton nuclear magnetic resonance relaxation parameters (T1, T2) were measured for over 100 malignant and normal tissue samples of various organs of the human body. The purpose of this study was to estimate the reliability of the NMR technique in discriminating normal from malignant tissues. Breast and cervix samples were analyzed by using the malignancy index concept and we were able to distinguish malignant and normal tissue in 17 out of 18 breast samples and 5 out of 7 cervix samples. Since the relaxation data of a normal control population of the other organs were not available, the data for these are reported without any further analysis. The distinction between carcinomas and sarcomas was also made by using the estimated relaxation parameters. Malignancy indices of breast tissue samples for linear least-squares and nonlinear two-parameter and three-parameter least-squares procedures were calculated and used to evaluate the relative efficiencies in discriminating malignant from normal tissues.
对人体多个器官的100多个恶性和正常组织样本测量了质子核磁共振弛豫参数（T1、T2）。本研究的目的是评估核磁共振技术在区分正常组织和恶性组织方面的可靠性。通过使用恶性指数概念对乳腺和宫颈样本进行分析，我们能够在18个乳腺样本中的17个以及7个宫颈样本中的5个中区分出恶性组织和正常组织。由于没有其他器官正常对照人群的弛豫数据，因此对这些数据未作进一步分析就进行了报告。还利用估计的弛豫参数区分了癌和肉瘤。计算了乳腺组织样本在线性最小二乘法、非线性双参数和三参数最小二乘法中的恶性指数，并用于评估区分恶性组织和正常组织的相对效率。
