Ling C R, Foster M A, Mallard J R
Br J Cancer. 1979 Dec;40(6):898-902. doi: 10.1038/bjc.1979.283.
In separate experiments, normal foreign tissue and malignant tumour were implanted s.c. into the rat thigh. NMR T1 values of the adjacent normal muscle, resulting from local inflammatory reactions or from malignant invasion, were measured. Elevations in T1 of the underlying muscle occurred within 24 h in both experiments, and it is believed these were caused by rapid inflammatory and immunological reactions to the implants. However the T1 values of muscle samples adjacent to the non-malignant implants decreased during the 11 days after implantation, dropping to values within the normal range. In the second experiment there was progressive malignant invasion into the normal adjacent tissue and the elevated T1 values were maintained throughout the 12-day period. The effects of the implantation on tissue water content are discussed in relation to NMR T1 relaxation times, and the relevance to whole-body NMR imaging of elevated T1 values due to nonmalignant pathological states is considered.
在单独的实验中，将正常异体组织和恶性肿瘤皮下植入大鼠大腿。测量了因局部炎症反应或恶性浸润导致的相邻正常肌肉的核磁共振T1值。在两个实验中，植入物下方肌肉的T1值在24小时内均升高，据信这是对植入物的快速炎症和免疫反应所致。然而，与非恶性植入物相邻的肌肉样本的T1值在植入后的11天内下降，降至正常范围内的值。在第二个实验中，恶性肿瘤逐渐侵入相邻正常组织，并且在整个12天期间T1值一直保持升高。结合核磁共振T1弛豫时间讨论了植入对组织含水量的影响，并考虑了非恶性病理状态导致的T1值升高与全身核磁共振成像的相关性。
