Kessel D, Sykes E, Henderson M
J Natl Cancer Inst. 1977 Jul;59(1):29-32. doi: 10.1093/jnci/59.1.29.
Elevated levels of three plasma glycosyltransferases were associated with neoplasia in cancer patients, notably those with tumor metastatic to liver. We examined levels of sialyltransferase, galactosyltransferase, and fucosyltransferase in metastatic tumor and apparently uninvolved host liver tissue in attempts to delineate possible sources of elevated plasma enzyme levels. Highest levels of fucosyltransferase activity were found associated with tumor tissue; in contrast, sialyltransferase and galactosyltransferase activity was often highest at the tumor-liver interface.
三种血浆糖基转移酶水平升高与癌症患者的肿瘤形成有关，尤其是那些肿瘤转移至肝脏的患者。我们检测了转移性肿瘤以及明显未受累的宿主肝脏组织中的唾液酸转移酶、半乳糖基转移酶和岩藻糖基转移酶水平，试图确定血浆酶水平升高的可能来源。发现岩藻糖基转移酶活性最高的水平与肿瘤组织相关；相比之下，唾液酸转移酶和半乳糖基转移酶活性通常在肿瘤与肝脏的界面处最高。
