Fielding J F
Digestion. 1981;22(3):155-8. doi: 10.1159/000198627.
The overall effect of the beta-blocker timolol maleate was not significantly different from placebo in patients with the irritable bowel syndrome on a high fibre diet. However, all 3 symptom-free patients were on timolol maleate. If beta-blockers have a major role to play in the treatment of the irritable bowel syndrome it must be through a central rather than a peripheral effect.
对于高纤维饮食的肠易激综合征患者，马来酸噻吗洛尔的总体疗效与安慰剂相比无显著差异。然而，所有3名无症状患者均服用了马来酸噻吗洛尔。如果β受体阻滞剂在肠易激综合征的治疗中起主要作用，那必定是通过中枢作用而非外周作用。
