Snook J, Shepherd H A
Royal Hampshire County Hospital, Winchester, UK.
Aliment Pharmacol Ther. 1994 Oct;8(5):511-4. doi: 10.1111/j.1365-2036.1994.tb00323.x.
Irritable bowel syndrome remains the commonest reason for referral to a gastroenterology clinic. Patients with irritable bowel syndrome are frequently advised to increase their intake of bran fibre, despite inconclusive experimental evidence of benefit.
The effect of dietary supplementation with a bolus of bran fibre (12 g/day) was studied in a block-randomized, placebo-controlled, crossover study of 80 patients with irritable bowel syndrome referred to a District General Hospital outpatient clinic. Comparison of the benefits of bran and placebo was based upon personal assessment of individual and overall symptom profiles, determined from a simple daily symptom score and post-treatment interview.
Overall symptomatic improvement was reported with bran by 52% and with placebo by 54% of patients. Bran supplementation was no more effective than placebo in improving individual symptoms of irritable bowel syndrome, and for wind-related symptoms it was significantly less effective (P < 0.001).
Dietary supplementation with bran is of no value in the treatment of patients with irritable bowel syndrome referred to a hospital clinic.
肠易激综合征仍然是转诊至胃肠病诊所的最常见原因。尽管关于麸皮纤维益处的实验证据尚无定论，但肠易激综合征患者经常被建议增加麸皮纤维的摄入量。
在一项对转诊至一家地区综合医院门诊的80例肠易激综合征患者进行的区组随机、安慰剂对照、交叉研究中，研究了大剂量麸皮纤维（12克/天）膳食补充剂的效果。麸皮和安慰剂益处的比较基于对个体和总体症状概况的个人评估，这些评估由简单的每日症状评分和治疗后访谈确定。
报告称，52%的患者服用麸皮后总体症状改善，54%的患者服用安慰剂后总体症状改善。补充麸皮在改善肠易激综合征个体症状方面并不比安慰剂更有效，对于与肠胃气胀相关的症状，其效果明显较差（P<0.001）。
对于转诊至医院诊所的肠易激综合征患者，膳食补充麸皮对治疗无效。
