Abrahamsson H, Lyrenäs E, Dotevall G
Dig Dis Sci. 1983 Jul;28(7):590-4. doi: 10.1007/BF01299918.
Effects of propranolol and metoprolol on sigmoid colonic motility were studied in 12 healthy volunteers in a double-blind randomized fashion. Colonic pressure was recorded 15-18 cm from anus and contractile activity quantified for periods of 25 min. On separate days propranolol, metoprolol, and placebo, respectively, was administered intravenously preceded by a control period. After propranolol, 10 mg intravenously, pressure activity increased significantly from 3.8 +/- 1.1 (SEM) kPa X min (28 +/- 8 mm Hg X min) to 5.9 +/- 1.0 kPa X min (44 +/- 8 mm Hg X min) (P less than 0.001). Also, after propranolol, 5 mg intravenously, the pressure activity was increased (P less than 0.05). After metoprolol, 10 mg intravenously, contractile activity increased from 4.3 +/- 0.9 kPa X min (32 +/- 7 mm Hg X min) to 6.1 +/- 1.0 kPa X min (46 +/- 8 mm Hg X min) (P less than 0.01). The two drugs caused equipotent reduction of heart rate. After placebo, no effect on sigmoid pressure or heart rate was observed. The study shows that unselective (propranolol) and beta 1-selective (metoprolol) beta-blocking drugs enhance distal colonic pressure in man. Colonic motility seems to be under sympathetic beta-adrenergic influence even under fairly unstrained conditions.
在12名健康志愿者中以双盲随机方式研究了普萘洛尔和美托洛尔对乙状结肠运动的影响。在距肛门15 - 18厘米处记录结肠压力，并对25分钟时间段内的收缩活动进行量化。在不同日期，分别在静脉注射普萘洛尔、美托洛尔和安慰剂之前设置一个对照期。静脉注射10毫克普萘洛尔后，压力活动从3.8±1.1（标准误）千帕×分钟（28±8毫米汞柱×分钟）显著增加至5.9±1.0千帕×分钟（44±8毫米汞柱×分钟）（P<0.001）。同样，静脉注射5毫克普萘洛尔后，压力活动也增加了（P<0.05）。静脉注射10毫克美托洛尔后，收缩活动从4.3±0.9千帕×分钟（32±7毫米汞柱×分钟）增加至6.1±1.0千帕×分钟（46±8毫米汞柱×分钟）（P<0.01）。这两种药物对心率的降低作用相当。注射安慰剂后，未观察到对乙状结肠压力或心率有影响。该研究表明，非选择性（普萘洛尔）和β1选择性（美托洛尔）β受体阻滞剂可增强人体远端结肠压力。即使在相当放松的条件下，结肠运动似乎也受交感神经β肾上腺素能的影响。
