Ghosh S N, Shah P N
Med Hypotheses. 1981 Aug;7(8):1099-104. doi: 10.1016/0306-9877(81)90106-7.
One of the X-chromosomes by a random inactivation process condenses to form X-chromatin (Barr body) in early embryonic life. Once this occurs, it is final and fixed for that cell and all its descendants (1,2). However, numerous investigators have observed extreme variations in Barr body frequency in tumour cells. For example, Sohval and Gains (3) reported an absence of the characteristic Barr body pattern of 19 of the 27 teratomas from females and Moore and Barr (4) observed significant variation in Barr body counts in breast cancer cells. Furthermore, a good correlation was made between the frequency of Barr body and prognosis (5,6,7,8,9). From a retrospective study, it was shown that tumours with low Barr body frequency (BBF) had a significant correlation with blood vessel invasion (BVI) and poor prognosis (10). But the reason why patients with low BBF in the tumor with BVI get early recurrence is not known. In this paper an attempt has been made to suggest a mechanism which may be involved in reducing the BBF with high malignant potentiality.
在胚胎早期生活中，一条X染色体通过随机失活过程浓缩形成X染色质（巴氏小体）。一旦发生这种情况，对于该细胞及其所有后代来说就是最终且固定的（1,2）。然而，许多研究者观察到肿瘤细胞中巴氏小体频率存在极大差异。例如，索瓦尔和盖恩斯（3）报告称，27例女性畸胎瘤中有19例缺乏典型的巴氏小体模式，摩尔和巴尔（4）观察到乳腺癌细胞中巴氏小体计数存在显著差异。此外，巴氏小体频率与预后之间存在良好的相关性（5,6,7,8,9）。一项回顾性研究表明，巴氏小体频率低（BBF）的肿瘤与血管侵犯（BVI）及不良预后显著相关（10）。但血管侵犯性肿瘤中巴氏小体频率低的患者早期复发的原因尚不清楚。本文试图提出一种可能参与降低具有高恶性潜能肿瘤的巴氏小体频率的机制。
