Fraser C M, Venter J C, Kaliner M
N Engl J Med. 1981 Nov 12;305(20):1165-70. doi: 10.1056/NEJM198111123052001.
We identified autoantibodies to beta 2-adrenergic receptors in the plasma of three apparently normal subjects, four patients with allergic asthma, one subject who was "preallergic" (at risk of allergy), and one patient with cystic fibrosis. Although these antibodies appeared to be heterogeneous, they shared the ability to affect binding of [125]protein A to calf-lung membranes, to inhibit beta-adrenergic ligand binding to calf-lung bet-adrenergic receptors, and to precipitate solubilized calf-lung beta-adrenergic receptors in an indirect immunoprecipitation assay. The presence of autoantibodies to beta-adrenergic receptors in these subjects correlates with abnormal autonomic responsiveness characterized by alpha-adrenergic and cholinergic hypersensitivity and beta-adrenergic hyposensitivity. These findings suggest that autoantibodies to beta-adrenergic receptors may play a part in the development of ment of autonomic abnormalities.
我们在三名表面正常的受试者、四名过敏性哮喘患者、一名“过敏前期”（有过敏风险）的受试者以及一名囊性纤维化患者的血浆中鉴定出了β2 - 肾上腺素能受体自身抗体。尽管这些抗体似乎具有异质性，但它们都具有影响[125]蛋白A与小牛肺膜结合、抑制β - 肾上腺素能配体与小牛肺β - 肾上腺素能受体结合以及在间接免疫沉淀试验中沉淀溶解的小牛肺β - 肾上腺素能受体的能力。这些受试者中β - 肾上腺素能受体自身抗体的存在与以α - 肾上腺素能和胆碱能超敏反应以及β - 肾上腺素能低敏反应为特征的自主神经反应异常相关。这些发现表明，β - 肾上腺素能受体自身抗体可能在自主神经异常的发生发展中起作用。
