Povýsil C, Matĕjovský Z
Virchows Arch A Pathol Anat Histol. 1981;393(2):233-44. doi: 10.1007/BF00431079.
Electron microscopic examination of three adamantinomas of long bones revealed structures usually observed in both mesenchymal and epithelial tumours. Tumour cells showing high alkaline phosphatase activity frequently tended to line clefts in connective tissue, resembling endothelial cells. The long processes of such cells showed fenestration. In areas showing fibre production the tumour cells were in close relationship to collagen fibrils. The latter were found, together with microfibrils, between the processes and above the basement membranes. The tumour cells were interconnected by desmosomes with tonofilaments and contained numerous bundles of microfilaments. All three cases revealed tiny intracytoplasmic inclusions resembling Weibel-Palade endothelial bodies. In addition, some of the structures in the lumena contained definite acid mucosubstances. A squamous cell pattern was present in only one of the three specimens. The coincidence of divergent structures in a single specimen has led us to the conclusion that the so-called adamantinoma of long bone might be possibly related to tumours of mesodermal or mesectodermal origin.
对三例长骨造釉细胞瘤进行电子显微镜检查，发现了通常在间充质肿瘤和上皮肿瘤中都能观察到的结构。显示高碱性磷酸酶活性的肿瘤细胞常常倾向于排列在结缔组织的裂隙中，类似于内皮细胞。这类细胞的长突起呈现出窗孔状。在显示纤维生成的区域，肿瘤细胞与胶原纤维关系密切。在突起之间以及基底膜上方发现了胶原纤维和微纤维。肿瘤细胞通过带有张力丝的桥粒相互连接，并含有大量微丝束。所有三例均显示出类似于魏贝尔-帕拉德内皮小体的微小胞质内包涵体。此外，管腔中的一些结构含有特定的酸性粘多糖物质。在三个标本中只有一个呈现出鳞状细胞模式。单个标本中不同结构的巧合使我们得出结论，所谓的长骨造釉细胞瘤可能与中胚层或中外胚层起源的肿瘤有关。
